Join or Sign In

Trifexis for Dogs

  • Free Shipping Item!
  • Rx Required

    Prescription Required

    A prescription is required for this product. Once we receive your order, we’ll quickly contact your vet and ship your prescription within one business day of receiving approval.

    * If you have a prescription in hand, select the "mail my prescription" option during checkout.

    * UPS doesn't ship on Saturday, Sunday, & major holidays. Note: If you are ordering medication, shipping is not available in the following states: LA.

$89.95 - $124.98

Quantity Discounts

Save Time and Money With Auto Ship!

Get your pet’s favorite products delivered on the schedule you set.

Save an extra time on this item when you schedule a recurring

Auto Ship order. Prices may change over time.

Product Details

Allow your dog to spend hours playing outside without worrying that he/she will become infected with heartworms, fleas, and intestinal worms. Trifexis is a chewable tablet that you can give once a month in order to kill fleas, prevent flea infestations, protect against heartworm disease, and treat/control adult hookworm, roundworm, and whipworm infections.

What is Trifexis? Trifexis is an oral preventative medication that can be given every 30 days to provide protection against fleas, heartworm, disease, and common intestinal parasites. It works to kill fleas, prevent flea infestations, protect against heartworm disease, and treat/control adult hookworm, roundworm, and whipworm infections.

Formulated for: dogs and puppies. Puppies need to be 8 weeks of age or older and must weigh 5 lbs or more in order to receive this medication safely.

How does this medication work? Milbemycin oxime and spinosad are the main ingredients that help to protect your dog from heartworms, fleas, and intestinal parasites. Milbemycin oxime works to help prevent heartworm disease. It works to kill the immature form of the heartworm (Dirofilaria immitis) before heartworms have the chance to develop into adults that can cause active disease. Milbemycin is also effective in killing common adult intestinal parasites (hookworms, roundworms, and whipworms) that can cause problems in your dog. Spinosad helps to kill fleas and prevent future flea infestations by killing adult fleas and immature fleas.

What results can I expect? Trifexis works almost immediately. It starts to kill fleas within 30 minutes and can kill 100% of all biting fleas within 4 hours. It is also effective in killing flea eggs which interrupts the flea life cycle. Trifexis also prevents heartworm disease by killing microfilariae and larvae. This prevents them from developing into adults. You can also expect Trifexis to help treat and control roundworms, hookworms, and whipworms.

What Form(s) does Trifexis come in? This medication is a tablet that is flavored and chewable.

Generic Name: Milbemycin oxime plus spinosad (Common Drug Name)

Common Brand Name: Trifexis (Elanco).

Drug and Food Interactions: Always tell your veterinarian about any medications, vitamins, or supplements your dog is taking before you start giving him/her Trifexis. Some serious adverse reactions have been documented when spinosad and ivermectin at doses higher than the heartworm prevention dose were used simultaneously. No known food interactions have been reported.

Uses: Trifexis is given to dogs one time per month in order to prevent heartworm disease, kill fleas, prevent flea infestations, and treat/control adult hookworm, roundworm, and whipworm infections.

Possible Side Effects: If using Trifexis at the recommended dosage, side effects are rare. Symptoms of gastrointestinal distress and skin irritation can occur. Vomiting, diarrhea, lethargy (decreased activity), lack of appetite, and itching and reddening of the skin are possible. If you observe any of these signs or any unusual symptoms in your dog once Trifexis has been administered, contact your veterinarian immediately. Vomiting may be more likely in puppies under 14 weeks of age. If your dog is truly allergic to Trifexis or to the dying of parasites, he/she may exhibit symptoms such as facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If your dog experiences any of these symptoms, call your veterinarian or a local emergency veterinarian immediately.
  • Protects against 5 different types of parasites: fleas, heartworms, roundworms, hookworms, and whipworms.
  • Kills fleas and helps to prevent flea infestations.
  • Combination of 2 active ingredient helps to keep your dog well protected.
  • Tablets are chewable and flavored allowing for easy administration.
  • Orally administered so there is no mess and no stress that other pets can lick medication.

Dose and Administration: Trifexis is a chewable tablet that should be given by mouth (orally) with food in order to achieve the maximal effect. It is given once a month seasonally or year-round. Try to administer each dose on the same day every month.

Follow your veterinarians instructions regarding the use of Trifexis. Generally, Once a month administration is what is most common. You may be directed to give this medication every month or just in warm months when mosquitoes and fleas are most prevalent. There are several sizes of this medication available that are based on your dogs body weight.

If you are giving Trifexis seasonally, it should be administered during and 3 months beyond the mosquito season, preferably on the same date each month. Treatment with less than 3 monthly doses after the last exposure to mosquitoes may not be effective.

This medication should not be given to any dogs other than the one that your veterinarian prescribes it for. Do not split tablets.

If you miss a dose, give it as soon as you remember. If more than one month has passed since the last dose of Trifexis, check with your veterinarian as a repeat heartworm test may be necessary.

Contact your veterinarian regarding Trifexis if you have further questions or if you are not sure how to administer this medication properly.

Storage: This medication should be stored in a tight, light-resistant, childproof container at room temperature. Keep out of reach of children and pets.

A prescription from your veterinarian is required to purchase Trifexis.
SKU: 51082

Sale!

Reviews

REVIEW SNAPSHOT®

by PowerReviews
Trifexis for Dogs
 
4.2

(based on 14 reviews)

Ratings Distribution

  • 5 Stars

     

    (6)

  • 4 Stars

     

    (7)

  • 3 Stars

     

    (0)

  • 2 Stars

     

    (0)

  • 1 Stars

     

    (1)

93%

of respondents would recommend this to a friend.

Pros

  • Easy to use (10)
  • Effective (10)
  • Long-lasting (8)
  • Gentle (6)
  • No side effects (6)

Cons

  • Difficult to administer (3)

Best Uses

      • Reviewer Profile:
      • Long-time pet owner (13)

    Most Liked Positive Review

     

    Trifexis

    My big dog has been on Trifexis for several years and he has never had any side effects from it. It is a bit expensive from my vet and I am going to start...Read complete review

    My big dog has been on Trifexis for several years and he has never had any side effects from it. It is a bit expensive from my vet and I am going to start ordering it online.
    The only negative thing I can say about this medication is, my dog hates the taste and won't chew it. My dog eats dry dog food but every month I have to give him wet dog food with the Trifexis tablet crushed up and mixed in it. This is the only way he will eat it.
    It would be nice if this medication would come in a capsule so I could just have my dog swallow it.

    VS

    Most Liked Negative Review

     

    Not effective, Elanco no help

    We have been giving our 11 month old mix Trifexis at the recommendation of our vet since we have had him (6 months). Two weeks after his latest dose, he was seeming lethargic...Read complete review

    We have been giving our 11 month old mix Trifexis at the recommendation of our vet since we have had him (6 months). Two weeks after his latest dose, he was seeming lethargic and we needed a new box of Trifexis, so we decided to take him in for the regular check-up he was slightly overdue for. At the check-up, his fecal came back positive for hookworms; thinking that surely Elanco's satisfaction guarantee would cover treatment, we gave him a prescription of Drontal ($56) at our vet's recommendation. Now, after both myself and my vet have talked to the Elanco rep, we have been told that Elanco will not honor any guarantee since the infection was discovered as part of a regular check-up. I understand that the worm has a short cycle and it is possible that he could test positive that soon after a dose, but based on his possible exposure I find it unlikely (clean yard) and the reaction of Elanco has left me extremely displeased. We will not continue treating with Trifexis, and I certainly would not recommend the product to others.

    Reviewed by 14 customers

    Sort by

    Displaying reviews 1-5

    Back to top

    Previous | Next »

    (1 of 2 customers found this review helpful)

     
    4.0

    no ticks no fleas happy dog

    By Biscuit526

    from Stuart, FL

    About Me Long-time Pet Owner

    Pros

    • Effective
    • Long-Lasting

    Cons

    • Difficult To Administer

    Best Uses

    • Geared Toward Weight

    Comments about Trifexis for Dogs:

    We use Trifexis monthly and are pleased with the fact that we never have to worry about fleas or ticks. It is one pill once monthly with no additional need for other preventative/protective preparations. It is quite expensive but when you add prices of alternative meds/preparations and that it is one thing adminIsterd monthly, the cost is reasonable. None of my dogs have enjoyed taking it, so I have had to disguise it in a variety of ways and watch closey to make.sure they do receive it.

    Comment on this review

    (3 of 3 customers found this review helpful)

     
    1.0

    Not effective, Elanco no help

    By DanielInAL

    from AL

    About Me Long-time Pet Owner

    Pros

    • Easy To Use

    Cons

    • Ineffective
    • Worthless Guarantee

    Best Uses

      Comments about Trifexis for Dogs:

      We have been giving our 11 month old mix Trifexis at the recommendation of our vet since we have had him (6 months). Two weeks after his latest dose, he was seeming lethargic and we needed a new box of Trifexis, so we decided to take him in for the regular check-up he was slightly overdue for. At the check-up, his fecal came back positive for hookworms; thinking that surely Elanco's satisfaction guarantee would cover treatment, we gave him a prescription of Drontal ($56) at our vet's recommendation. Now, after both myself and my vet have talked to the Elanco rep, we have been told that Elanco will not honor any guarantee since the infection was discovered as part of a regular check-up. I understand that the worm has a short cycle and it is possible that he could test positive that soon after a dose, but based on his possible exposure I find it unlikely (clean yard) and the reaction of Elanco has left me extremely displeased. We will not continue treating with Trifexis, and I certainly would not recommend the product to others.

      Comment on this review

      (2 of 2 customers found this review helpful)

       
      4.0

      trifexis

      By pascualjr

      from mililani, HI

      About Me Long-time Pet Owner

      Pros

      • Effective

      Cons

        Best Uses

          Comments about Trifexis for Dogs:

          Very effective product. Previously used Frontline topical & Comfortis tablet but both prove ineffective for fleas in my area.

          Comment on this review

          (4 of 4 customers found this review helpful)

           
          4.0

          Good Product

          By hsaxon01

          from Pittsburgh, PA

          About Me Long-time Pet Owner

          Pros

          • Easy To Use
          • Effective
          • Long-Lasting
          • No Side Effects

          Cons

          • Difficult To Administer

          Best Uses

            Comments about Trifexis for Dogs:

            I like that the product works for both fleas and heartworm. My only complaint is that the tablet smells horrible and my dog wouldn't touch it, unlike heartguard which he thinks is a treat. I attempted to break the tablet into small pieces and hide it in a piece of lunch meat but he still smelled it and refused to eat it. I then crushed it up and mixed it with peanut butter (which he loves) and that seemed to do the trick. If the manufacturer would just make it more palatable to dogs this would be the perfect solution. I was a little nervous after reading some reviews on here but my dog showed no abnormal symptoms after taking the medication.

            Comment on this review

            (1 of 1 customers found this review helpful)

             
            4.0

            Trifexis

            By 3 dog owner

            from Florida

            About Me Long-time Pet Owner

            Pros

            • Easy To Use

            Cons

            • My Dogs Didn't Like Taste

            Best Uses

            • Monthly Flea Treatment

            Comments about Trifexis for Dogs:

            My 3 dogs didn't like the taste or smell of the tablet. I used meat to mask the taste/smell. I did have to break the tablet as they are a little big for our Cockers.
            This is their first treatment, they did seem to itch a lot but I assume that was the med working.
            The itching has subsided, will continue using Trifexis.

            Comment on this review

            Displaying reviews 1-5

            Back to top

            Previous | Next »