NEXGARD (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. NEXGARD kills adult fleas and is indicated for the treatment and prevention of flea infestations, treatment of American Dog tick infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds or greater. Give by mouth once a month. This product can be given with or without food. Active ingredient in NexGard is afoxolaner, which kills fleas and ticks by attacking their nervous system. NexGard is for use only in dogs.